Calypsol
$160.00 – $650.00Price range: $160.00 through $650.00
Buy Calypsol Online Without Prescription
Buy Calypsol is a noncompetitive N-methyl-D-aspartate receptor antagonist that blocks glutamate. It has a direct action on the cortex and limbic system. It produces a cataleptic-like state wherein the patient is withdrawn from the surrounding environment.
Calypsol is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. The anesthetic state produced by Calypsol has been termed as “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticular-activating and limbic systems).
Key Uses
It serves as a sole anesthetic for short diagnostic or surgical procedures not requiring muscle relaxation, such as minor operations or pain relief during exams. Calypsol also induces anesthesia before other agents or supplements, low-potency ones like nitrous oxide, and it’s suitable for patients with asthma due to bronchodilation effects.
Mechanism
Calypsol acts as a noncompetitive NMDA receptor antagonist, blocking glutamate and producing “dissociative anesthesia” that disconnects sensory pathways while preserving reflexes and muscle tone.
Side Effects
Common issues include emergence reactions like hallucinations or confusion, elevated blood pressure, tachycardia, nausea, and respiratory effects such as laryngospasm. It’s administered via injection with rapid absorption and high bioavailability of around 93%.
Psychiatric Effects
These include vivid dreams, hallucinations, confusion, and irrational behavior, affecting 10-20% of adults. Nystagmus, diplopia, and alterations in mood also occur frequently.
Cardiovascular Effects
Patients often experience temporary hypertension, tachycardia, or arrhythmias due to sympathetic stimulation.
Other Common Issues
Nausea, vomiting, hypersalivation, laryngospasm, respiratory depression, and injection site pain are typical. Dizziness, blurred vision, and increased intraocular pressure round out frequent complaints.
Neurological Risks
Seizures, coma, encephalopathy, or nerve problems like numbness, weakness, or drooping eyelids occur rarely, especially in children under 3. Hallucinations, psychosis, or holding false beliefs are also possible severe psychiatric reactions.
Respiratory & Cardiac Issues
Apnea, respiratory depression, laryngospasm, or irregular heartbeat leading to hypotension or myocardial infarction are uncommon but critical. Chest pain or trouble breathing may signal life-threatening complications.
Organ Damage
Liver problems (hepatobiliary dysfunction), with symptoms like jaundice or dark urine, and ulcerative cystitis from chronic use cause pain, hematuria, or reduced bladder capacity. Rhabdomyolysis or acute kidney injury are overdose-related rarities.
Contraindications
Avoid in patients with hypertension, history of cerebrovascular accident or stroke, eye injuries, elevated intraocular pressure (e.g., glaucoma), raised intracranial or CSF pressure, psychotic disorders like schizophrenia, or conditions where blood pressure elevation is hazardous.
Precautions
Use caution in those with cardiac decompensation, chronic alcoholism, or acute intoxication, pre-anesthetic elevated CSF pressure, dependence risk, pregnancy, lactation, head injuries, hydrocephalus, hyperthyroidism, hypovolemia, or pulmonary infections. Minimize stimulation during recovery, monitor cardiac function continuously, and avoid driving or operating machinery afterward. It may interact adversely with CNS depressants, thyroid hormones, antihypertensives, or alcohol.
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